Functional MRI in Clinical Research and Practice
Functional MRI in Clinical Research and Practice: Measurement, Design and Analysis is designed to give clinical investigators an intensive introduction to the issues associated with using structural and functional MRI in proposing, executing and reporting clinical research studies. Topics will include the basic principles of MRI measurement, techniques for stimulus presentation and response recording in high magnetic fields, basic statistical methods, individual subject experimental design and analysis techniques, group design and analysis techniques, clinical study design principles and guidelines for proposing and reporting clinical neuroimaging studies.
Emphasis will be given to the current and potenial future use of functional MRI in clinical practice, including its growing role in supporting pre-surgical planning.
Each afternoon will end with an Experimental Design Workshop session, in which participants will gather in small groups to work through the stages of designing a clinical study using stuctural and functional neuroimaging endpoints. The final session will include presentations of these projects.
The level of the presentations will be appropriate for both early and mid-career clinical investigators planning to use measures of brain structure and function in clinical studies. The course website will provide extensive guidance for subsequent self-study.
Information about accomodations may be found here.
Register for the course here.
The courses will be held in the 3rd floor conference room at the Constitution Inn in Charlestown, MA.. Parking is available nearby.
Questions about course arrangements or content should be directed to admin@neurometrika.org
The course instructors are Thomas Zeffiro and Robert Savoy.
Course dates: October 17-21, 2011
The fee for the program is $1500. Reduced rates of $1250 for post-doctoral fellows and $1000 for undergraduate, graduate or medical students are available. A 20% discount is available to all MGH and MIT investigators.
Tentative Schedule
DAY ONE - Introduction
9:00am-10:00am Workshop Overview: Planning a Clinical fMRI Study - TZ
10:00am-11:00pm Overview of fMRI - RLS
11:00am-12:00pm Basic Block Design - RLS
12:00pm-1:00pm LUNCH
1:00pm-2:00pm Participant Screening, Characterization and Selection - TZ
2:00pm-3:00pm Behavioral Measurements In and Out of the Magnet - TZ
3:00pm-5:00pm Study Design and Analysis Workshop - RLS and TZ
DAY TWO - Measurement and Task Design
9:00am-10:00am MRI Physics - RLS
10:00am-11:00pm Optimal fMRI Data Acquisition: Spatial - TZ
11:00am-12:00pm Optimal fMRI Data Acquisition: Temporal - TZ
12:00pm-1:00pm LUNCH
1:00pm-2:00pm Experimental Task Design: Principles - RLS
2:00pm-3:00pm Experimental Task Design: Examples - RLS and TZ
3:00pm-5:00pm Study Design and Analysis Workshop - RLS and TZ
DAY THREE - Study Design and Preprocessing
10:00am-11:00am Study Design: Examples - TZ
11:00am-12:00pm Single-Subject Analysis Overview - TZ
12:00pm-1:00pm LUNCH
1:00pm-2:00pm Preprocessing: Unwarping, Realignment, Slice Timing -TZ
2:00pm-3:00pm Preprocessing: Spatial Normalization - TZ
3:00pm-5:00pm Study Design and Analysis Workshop - RLS and TZ
DAY FOUR - Statistical Analysis
10:00am-11:00am Single-Subject Analysis: Estimation - TZ
11:00am-12:00pm Single-Subject Analysis: Inference - TZ
12:00pm-1:00pm LUNCH
1:00pm-2:00pm Group Analysis: Design Specification - TZ
2:00pm-3:00pm Group Analysis: Estimation and Inference - TZ
3:00pm-5:00pm Study Design and Analysis Workshop - RLS and TZ
DAY FIVE
12:00pm-1:00pm LUNCH
3:00pm-5:00pm Study Design and Analysis Workshop - RLS and TZ
LECTURE SLIDES
LEC2 Broad Perspective and fMRI Introduction
LEC8 Optimizing fMRI Acquisition: Spatial
LEC9 Optimizing fMRI Acquisition: Temporal
LEC23 Visualization and Labeling
LEC25 Computational Neuroanatomy with Freesurfer