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Functional MRI in Clinical Research and Practice

Functional MRI in Clinical Research and Practice: Measurement, Design and Analysis is designed to give clinical investigators an intensive introduction to the issues associated with using structural and functional MRI in proposing, executing and reporting clinical research studies. Topics will include the basic principles of MRI measurement, techniques for stimulus presentation and response recording in high magnetic fields, basic statistical methods, individual subject experimental design and analysis techniques, group design and analysis techniques, clinical study design principles and guidelines for proposing and reporting clinical neuroimaging studies.

Emphasis will be given to the current and potenial future use of functional MRI in clinical practice, including its growing role in supporting pre-surgical planning.

Each afternoon will end with an Experimental Design Workshop session, in which participants will gather in small groups to work through the stages of designing a clinical study using stuctural and functional neuroimaging endpoints. The final session will include presentations of these projects.

The level of the presentations will be appropriate for both early and mid-career clinical investigators planning to use measures of brain structure and function in clinical studies. The course website will provide extensive guidance for subsequent self-study.

 

Information about accomodations may be found here.

Register for the course here.

The courses will be held in the 3rd floor conference room at the Constitution Inn in Charlestown, MA.. Parking is available nearby.

Questions about course arrangements or content should be directed to admin@neurometrika.org

The course instructors are Thomas Zeffiro and Robert Savoy.

Course dates: October 17-21, 2011

The fee for the program is $1500. Reduced rates of $1250 for post-doctoral fellows and $1000 for undergraduate, graduate or medical students are available.  A 20% discount is available to all MGH and MIT investigators.

Questions about the course arrangements or content should be directed to admin@neurometrika.org

 


Tentative Schedule 


DAY ONE - Introduction

9:00am-10:00am  Workshop Overview: Planning a Clinical fMRI Study - TZ
10:00am-11:00pm  Overview of fMRI - RLS
11:00am-12:00pm  Basic Block Design  - RLS
12:00pm-1:00pm  LUNCH
1:00pm-2:00pm  Participant Screening, Characterization and Selection - TZ
2:00pm-3:00pm  Behavioral Measurements In and Out of the Magnet - TZ
3:00pm-5:00pm  Study Design and Analysis Workshop - RLS and TZ

DAY TWO - Measurement and Task Design
Functional MRI Measurement
9:00am-10:00am  MRI Physics - RLS
10:00am-11:00pm Optimal fMRI Data Acquisition: Spatial - TZ
11:00am-12:00pm Optimal fMRI Data Acquisition: Temporal - TZ
12:00pm-1:00pm  LUNCH
1:00pm-2:00pm  Experimental Task Design: Principles - RLS
2:00pm-3:00pm Experimental Task Design: Examples - RLS and TZ
3:00pm-5:00pm  Study Design and Analysis Workshop - RLS and TZ
DAY THREE - Study Design and Preprocessing
9:00am-10:00am   Study Design: Principles - TZ
10:00am-11:00am  Study Design: Examples - TZ
11:00am-12:00pm Single-Subject Analysis Overview - TZ
12:00pm-1:00pm  LUNCH
1:00pm-2:00pm Preprocessing: Unwarping, Realignment, Slice Timing -TZ
2:00pm-3:00pm  Preprocessing: Spatial Normalization - TZ
3:00pm-5:00pm  Study Design and Analysis Workshop - RLS and TZ
DAY FOUR - Statistical Analysis
9:00am-10:00am    Single-Subject Analysis: Design Specification - TZ
10:00am-11:00am  Single-Subject Analysis: Estimation - TZ
11:00am-12:00pm  Single-Subject Analysis: Inference - TZ
12:00pm-1:00pm  LUNCH
1:00pm-2:00pm     Group Analysis: Design Specification - TZ
2:00pm-3:00pm     Group Analysis: Estimation and Inference - TZ
3:00pm-5:00pm     Study Design and Analysis Workshop - RLS and TZ
DAY FIVE

12:00pm-1:00pm    LUNCH

3:00pm-5:00pm     Study Design and Analysis Workshop - RLS and TZ

 

LECTURE SLIDES

LEC1 Overview

LEC2 Broad Perspective and fMRI Introduction

LEC3 Basic Block Design

LEC4 Selection

LEC5 Behavior

LEC6 Design Workshop

LEC7 MRI Physics and Safety

LEC8 Optimizing fMRI Acquisition: Spatial

LEC9 Optimizing fMRI Acquisition: Temporal

LEC10-11 Task Design

LEC12 Study Design Principles

LEC13 Study Design Examples

LEC14 Analysis Overview

LEC15 Preprocessing

LEC16 Spatial Normalization

LEC17-18 First Level

LEC19 Inference

LEC20-21 Second Level

LEC22 Reporting

LEC23 Visualization and Labeling

LEC24 Meta-analysis

LEC25 Computational Neuroanatomy with Freesurfer

Freesurfer paper


 

 

 

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